Link Between Psychiatric Disorders and Events During Prenatal Development Identified

Link Between Psychiatric Disorders and Events During Prenatal Development Identified

Summary: A new study reports genetic variants that are critical for the development of the brain during fetal development are also frequently found in psychiatric disorders.

Source: Aarhus University.

Particular genetic variants in the human genome that are important for the development of the brain early in the life of the foetus are frequently found in psychiatric disorders. This is shown by a study carried out by iPSYCH.

Researchers studied a total of eight million genetic variants and in connection with this they found that a number of these variants occur particularly often in people who have one of more of the following psychiatric disorders: schizophrenia, depression, bipolar disorder, autism and ADHD.

This background is provided by Professor Thomas Werge from the Mental Health Services & University of Copenhagen and the Lundbeck Foundation’s Initiative for Integrated Psychiatric Research, commonly referred to as iPSYCH, which has received a total of DKK 361 million in funding from the Lundbeck Foundation. He explains:

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General Blog Neuroscience & Psychology

A Fascinating Sign Of High IQ

A Fascinating Sign Of High IQ

This sleep pattern is linked to stronger reasoning and better analytical and conceptual thinking.

Despite higher intelligence, night owls tend to get slightly worse grades in school.

This may be because the school day starts too early for them.

Morning types who rise early, also known as ‘larks’, tend to do around 8% better in school.

Later in life, though, the higher intelligence of night owls tends to shine through.

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General Blog Neuroscience & Psychology

Want to Innovate? Science Says, “Be A Nonconformist!”

Want to Innovate? Science Says, “Be A Nonconformist!”

Creativity is a process of making something unique and useful, and this process can lead to innovation. Unique creations require flexibility of thought and skills to entertain and develop uncommon ideas, which are borne out of differing opinions, not consensus. Remarkable ideas that supersede current knowledge flourish in the presence of diverse intellectual perspectives where conformity and status quo are challenged. A diverse group can create distinctive ideas, drawing on the variety of experiences from different backgrounds, thoughts, views, and skills. Intellectual diversity, a multiplicity of ideas, philosophies, and perspectives, is the main contributor to creativity and innovation. However, when you are in a climate where intellectual diversity is not valued, you may be mistaken for a troublemaker. Notable innovators in history thought and behaved differently from others and were nonconformists. They were often misunderstood or seen as troublemakers, such as Click to read

General Blog Neuroscience & Psychology

Synesthesia: Hearing colors and tasting sounds

Synesthesia: Hearing colors and tasting sounds

Can you taste sounds or visualize symphonies of color whenever you hear a song? If your answer to these is “yes,” you may have a wonderful condition known as synesthesia, which you share with many great artists, writers, and musicians.

By his own account, Nabokov saw each letter in different colors, despite the fact that text was printed all-black on white paper.

Interestingly, both his wife and his son shared this fascinating ability, though they each saw different palettes of color for the alphabet.

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General Blog Neuroscience & Psychology

Men , women and memory

The study, published in JAMA Neurology, measured memory performance, brain structure according to lower hippocampal volume and the presence of amyloid – brain plaques associated with Alzheimer’s disease.

“Our objectives were to compare age, sex and APOE ε4 effects on memory performance, hippocampal volume and amyloid positron emission tomography (PET) across the adult lifespan,” write the authors.

APOE ε4 is a gene that is consistently identified as a risk factor for late-onset Alzheimer’s disease and has been found to significantly lower the age of onset for this condition. It is also recognized as a risk factor for early-onset Alzheimer’s disease as well.

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Neuroscience & Psychology

It’s on the Tip of My Tongue

It just happened to me the other day: I was watchingMarvel’s Agents of S.H.I.E.L.D. and there was a new guest star; I turned to my husband and said – “Oh I remember her – she was in ‘Angel’ and the new ‘Much Ado About Nothing’…Amy something or other….” And then I drove myself crazy trying to remember her name before giving up and searching it on IMDB (It’s Amy Acker).

We’ve all experienced moments like that before – what scientists call the “tip-of-the-tongue” phenomenon, or TOT – where we remember all sorts of things about something or someone but can’t seem to get the name out. Understanding how and why this happens is more than just a matter of helping us access random celebrity names: TOT opens a window into aphasia, a language disorder caused by stroke and other brain injuries in which people have a hard time remembering words and generating speech.

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Neuroscience & Psychology

What Alzheimer’s Patients Feel After Their Memories Have Vanished

While patients with Alzheimer’s might not remember when their loved ones visit, it has a profound effect on how they feel, a new study finds.

The study showed both happy and sad video clips lasting around 20 minutes to people with Alzheimer’s disease and observed their emotional states (Guzmán-Vélez et al., 2014).

They did the same for a group of healthy adults.

Five minutes afterwards, all the participants were given a memory test to see if they could remember the video they had just seen.

As you’d expect, Alzheimer’s patients remembered significantly less about the clips they’d just seen than the healthy group

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Neuroscience & Psychology

How Curiosity Changes the Brain to Enhance Learning

The more curious we are about a topic, the easier it is to learn information about that topic. New research publishing online October 2 in the Cell Press journal Neuron provides insights into what happens in our brains when curiosity is piqued. The findings could help scientists find ways to enhance overall learning and memory in both healthy individuals and those with neurological conditions.

“Our findings potentially have far-reaching implications for the public because they reveal insights into how a form of intrinsic motivation—curiosity—affects memory. These findings suggest ways to enhance learning in the classroom and other settings,” says lead author Dr. Matthias Gruber, of University of California at Davis.

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Neuroscience & Psychology

Neuroscience and Big Data: How to Find Simplicity in the Brain

Scientists can now monitor and record the activity of hundreds of neurons concurrently in the brain, and ongoing technology developments promise to increase this number manyfold. However, simply recording the neural activity does not automatically lead to a clearer understanding of how the brain works.

In a new review paper published in Nature Neuroscience, Carnegie Mellon University’s Byron M. Yu and Columbia University’s John P. Cunningham describe the scientific motivations for studying the activity of many neurons together, along with a class of machine learning algorithms — dimensionality reduction — for interpreting the activity

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Neuroscience & Psychology

Mothers transfer fear to their babies through odors

A phenomenon that has long baffled researchers is how the traumatic experience of a mother can affect her child – even when the event occurs before the baby is born. Inching closer to an explanation, a team of investigators studied mother rats and discovered how they transferred their fears to their pups during their early days of life – through odors released during distress.

The team, from the University of Michigan (U-M) Medical School and New York University, published their results in the journal Proceedings of the National Academy of Sciences.

They say their findings helped them identify the specific brain area where fear transmission settles during the early days of life, which could lead to a better insight as to why not all children of distressed mothers experience the same effects.

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Neuroscience & Psychology

Speaking a second language could prevent later-life cognitive decline

Can you speak two or more languages? If so, your brain may thank you for it later in life. New research published in the Annals of Neurology suggests that bilingualism may slow down age-related cognitive decline – even if a second language is learned in adulthood.

The research team, led by Dr. Thomas Bak of the Centre for Cognitive Aging and Cognitive Epidemiology at the University of Edinburgh in the UK, notes that recent studies have already indicated a link between bilingualism and delayed onset of cognitive decline and dementia.

But according to Dr. Bak: "Our study is the first to examine whether learning a second language impacts cognitive performance later in life while controlling for childhood intelligence."

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Neuroscience & Psychology

Bipolar Disorder

What Is Bipolar Disorder?

Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in mood, energy, activity levels, and the ability to carry out day-to-day tasks. Symptoms of bipolar disorder are severe. They are different from the normal ups and downs that everyone goes through from time to time. Bipolar disorder symptoms can result in damaged relationships, poor job or school performance, and even suicide. But bipolar disorder can be treated, and people with this illness can lead full and productive lives.

Signs & Symptoms

People with bipolar disorder experience unusually intense emotional states that occur in distinct periods called "mood episodes." Each mood episode represents a drastic change from a person’s usual mood and behavior. An overly joyful or overexcited state is called a manic episode, and an extremely sad or hopeless state is called a depressive episode. Sometimes, a mood episode includes symptoms of both mania and depression. This is called a mixed state. People with bipolar disorder also may be explosive and irritable during a mood episode.

Extreme changes in energy, activity, sleep, and behavior go along with these changes in mood. Symptoms of bipolar disorder are described below.

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Neuroscience & Psychology

Neuroscience’s Grand Question

When your car needs a new spark plug, you take it to a shop where it sits, out of commission, until the repair is finished. But what if your car could replace its own spark plug while speeding down the Mass Pike?

Of course, cars can’t do that, but our nervous system does the equivalent, rebuilding itself continually while maintaining full function.

Neurons live for many years but their components, the proteins and molecules that make up the cell are continually being replaced. How this continuous rebuilding takes place without affecting our ability to think, remember, learn or otherwise experience the world is one of neuroscience’s biggest questions.

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Neuroscience & Psychology

Some Patients with Schizophrenia Have Impaired Ability to Imitate According to Study

According to George Bernard Shaw, “Imitation is not just the sincerest form of flattery – it’s the sincerest form of learning.” According to psychologists, imitation is something that we all do whenever we learn a new skill, whether it is dancing or how to behave in specific social situations.

Now, the results of a brain-mapping experiment conducted by a team of neuroscientists at Vanderbilt University strengthen the theory that an impaired ability to imitate may underlie the profound and enduring difficulty with social interactions that characterize schizophrenia. In a paper published online on Mar. 14 by the American Journal of Psychiatry, the researchers report that when patients with schizophrenia were asked to imitate simple hand movements, their brains exhibited abnormal brain activity in areas associated with the ability to imitate.

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Neuroscience & Psychology

Brain Scans Show We Take Risks Because We Can’t Stop Ourselves

A new study correlating brain activity with how people make decisions suggests that when individuals engage in risky behavior, such as drunk driving or unsafe sex, it’s probably not because their brains’ desire systems are too active, but because their self-control systems are not active enough.

This might have implications for how health experts treat mental illness and addiction or how the legal system assesses a criminal’s likelihood of committing another crime.

When these brain regions (mostly associated with control) aren’t active enough, we make risky choices. Z-statistic corresponds to predictive ability, yellow being the most predictive regions. Credit Sarah Helfinstein/U. of Texas at Austin.

Researchers from The University of Texas at Austin, UCLA and elsewhere analyzed data from 108 subjects who sat in a magnetic resonance imaging (MRI) scanner — a machine that allows researchers to pinpoint brain activity in vivid, three-dimensional images — while playing a video game that simulates risk-taking.

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Neuroscience & Psychology